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Implementing the estimand framework in global drug development: Application of causal inference approaches

  • 15 Jan 2024 2:24 PM
    Message # 13301070

    The Australian Pharmaceutical Biostatistics Group is delighted to invite members and guests to join this workshop on Implementing the estimand framework in global drug development: Application of causal inference approaches.

    Date/Time:

    Thursday 1st February 7.30-11pm (Sydney time)

    Location:

    Virtual – please contact apbgsteering@gmail.com for meeting link

    Instructors:

    • Mouna Akacha, Novartis Pharma AG, Basel, Switzerland
    • Björn Bornkamp, Novartis Pharma AG, Basel, Switzerland
    • Alex Ocampo, Novartis Pharma AG, Basel, Switzerland
    • Jiawei Wei, Novartis Institutes for Biomedical Research Co., Shanghai, China

    Details:

    This evening short course introduces how causal inference approaches are relevant and used in the implementation of estimands framework in drug development. It includes 4 lectures:

    Lecture 1 – Introduction to Estimands and Causal Inference:

    1. Overview of the estimand framework and key points in ICH E9(R1)
    2. Introduction to causal inference, including potential outcomes, causal effects and common assumptions;

    Lecture 2 – Estimation Methods of Causal Effects Targeting at Hypothetical Estimands:

    1. Introduction to common estimation methods, e.g., g-computation, IPW (Inverse probability weighting)
    2. RCT examples illustrated using R code;

    Lecture 3 – Principal Stratum:

    1. Introduction to principal stratum estimand
    2. Estimation strategies
    3. Case studies in RCTs;

    Lecture 4 – Conditional and Marginal Treatment Effects:

    1. Introduction to conditional and marginal treatment effects
    2. Appropriate estimators for conditional and marginal estimands
    3. RCT examples illustrated using R code.


    Last modified: 16 Jan 2024 10:16 AM | Sandra Louw
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